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Details on Person LTA4 is converted to EXA4 by ALOX15

Class:Id	Reaction:2162019
_displayName	LTA4 is converted to EXA4 by ALOX15
_doRelease	TRUE
_timestamp	2016-11-10 00:54:55
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161993] leukotriene-C4 synthase activity of ALOX15:Fe2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:265281] LTA4 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161756] Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells [LiteratureReference:2161760] Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586592] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	LTA4 is converted to EXA4 by ALOX15
output	[SimpleEntity:2142772] EXA4 [cytosol]
precedingEvent	[Reaction:266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 [Homo sapiens] [Reaction:265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200160] R-HSA-2162019.3
summation	[Summation:2162056] Analogous to arachidonate 5-lipoxygenase (ALOX5) biosynthesi...
(hasEvent)	[Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Homo sapiens]
(precedingEvent)	[Reaction:2161768] EXA4 is converted to EXC4 by LTC4S [Homo sapiens]
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No pathways have been reviewed or authored by LTA4 is converted to EXA4 by ALOX15 (2162019)