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Details on Person Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 200...
| Class:Id | Summation:2162017 |
|---|---|
| _displayName | Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 200... |
| _timestamp | 2024-07-31 13:53:34 |
| created | [InstanceEdit:2161780] Williams, MG, 2012-03-14 |
| modified | [InstanceEdit:9917185] D'Eustachio, Peter, 2024-07-31 |
| text | Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 2007, Kuhn et al. 1993, Izumi et al. 1991) and arachidonate 15-lipoxygenase B (ALOX15B) (Tang et al. 2002, Wecksler et al. 2008) are lipid peroxidising enzymes mainly expressed in airway epithelial cells, eosinophils, reticulocytes and in macrophages. They insert molecular oxygen at C-6 from the omega-end of arachidonate with formation of the unstable intermediate 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) which can be further converted, enzymatically or non-enzymatically, to 15S-hydroxyeicosatetraenoic acid (15S-HETE). |
| (summation) | [Reaction:2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B [Homo sapiens] |
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No pathways have been reviewed or authored by Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 200... (2162017)
