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Details on Person Arachidonate is oxidised to 15S-HpETE by ALOX15/15B

Class:Id	Reaction:2162002
_displayName	Arachidonate is oxidised to 15S-HpETE by ALOX15/15B
_doRelease	TRUE
_timestamp	2024-07-31 13:54:18
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161832] arachidonate 15-lipoxygenase activity of ALOX15/15B [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915889] RHEA:16870
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:29768] AA [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2162040] Expression of 15-lipoxygenase type-1 in human mast cells [LiteratureReference:2162025] Overexpression, purification and characterization of human recombinant 15-lipoxygenase [LiteratureReference:2161786] Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes [LiteratureReference:2161928] Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells [LiteratureReference:2161754] Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2308243] D'Eustachio, P, 2012-06-04 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586591] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915896] D'Eustachio, Peter, 2024-07-17 [InstanceEdit:9917185] D'Eustachio, Peter, 2024-07-31
name	Arachidonate is oxidised to 15S-HpETE by ALOX15/15B (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
output	[SimpleEntity:2142718] 15S-HpETE [cytosol]
precedingEvent	[Reaction:428990] SLC27A1 transports arachidonate across the ER membrane [Homo sapiens] [Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200431] R-HSA-2162002.4
summation	[Summation:2162017] Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 200...
(hasEvent)	[Pathway:2142770] Synthesis of 15-eicosatetraenoic acid derivatives [Homo sapiens]
(precedingEvent)	[Reaction:2161791] 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 [Homo sapiens] [Reaction:2161917] ALOX5 oxidises 15S-HpETE to LXA4/B4 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919437] Update Tracker - [Reaction:2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B - v90:[modifyText]
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