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Details on Person Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2

Class:Id	Reaction:2161951
_displayName	Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2
_doRelease	TRUE
_timestamp	2024-07-31 13:54:15
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161919] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of Ac-PTGS2 dimer [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915890] RHEA:52497
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:29768] AA [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161778] Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2308243] D'Eustachio, P, 2012-06-04 [InstanceEdit:2316261] D'Eustachio, P, 2012-06-07 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586591] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915896] D'Eustachio, Peter, 2024-07-17 [InstanceEdit:9917185] D'Eustachio, Peter, 2024-07-31
name	Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:2142738] 15R-HETE [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:428990] SLC27A1 transports arachidonate across the ER membrane [Homo sapiens] [Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens] [Reaction:2314686] ASA- acetylates PTGS2 [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells [Homo sapiens] [Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200243] R-HSA-2161951.4
summation	[Summation:2161938] Aspirin acetylates the cyclooxygenase, prostaglandin G/H syn...
(hasEvent)	[Pathway:2142770] Synthesis of 15-eicosatetraenoic acid derivatives [Homo sapiens]
(precedingEvent)	[Reaction:2161907] ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919517] Update Tracker - [Reaction:2161951] Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 - v90:[modifyText]
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