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Details on Person Arachidonate is oxidised to 12R-HpETE by ALOX12B

Class:Id	Reaction:2161950
_displayName	Arachidonate is oxidised to 12R-HpETE by ALOX12B
_doRelease	TRUE
_timestamp	2024-07-31 13:54:09
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161752] arachidonate 12(S)-lipoxygenase activity of ALOX12B:Fe2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915910] RHEA:41337
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:29768] AA [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161771] A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2308243] D'Eustachio, P, 2012-06-04 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586591] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915896] D'Eustachio, Peter, 2024-07-17 [InstanceEdit:9917185] D'Eustachio, Peter, 2024-07-31
name	Arachidonate is oxidised to 12R-HpETE by ALOX12B (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
output	[SimpleEntity:2142790] 12R-HpETE [cytosol]
precedingEvent	[Reaction:428990] SLC27A1 transports arachidonate across the ER membrane [Homo sapiens] [Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200291] R-HSA-2161950.4
summation	[Summation:2161939] The arachidonate 12-lipoxygenase, 12R-type (ALOX12B) oxidise...
(hasEvent)	[Pathway:2142712] Synthesis of 12-eicosatetraenoic acid derivatives [Homo sapiens]
(precedingEvent)	[Reaction:2161959] 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 [Homo sapiens] [Reaction:8942208] ALOXE3 isomerises 12R-HpETE to HXA3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919458] Update Tracker - [Reaction:2161950] Arachidonate is oxidised to 12R-HpETE by ALOX12B - v90:[modifyText]
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