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Details on Person ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4

Class:Id	Reaction:2161907
_displayName	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4
_doRelease	TRUE
_timestamp	2018-11-12 17:13:06
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161852] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:2142738] 15R-HETE [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161778] Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2308252] D'Eustachio, P, 2012-06-05 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586590] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9037802] Jassal, Bijay, 2018-02-21 [InstanceEdit:9628713] Jassal, Bijay, 2018-11-12 [InstanceEdit:9628714] Jassal, Bijay, 2018-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4
output	[DefinedSet:2161609] 15epi-LXA4/B4 [cytosol]
precedingEvent	[Reaction:2161951] Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 [Homo sapiens] [Reaction:428990] SLC27A1 transports arachidonate across the ER membrane [Homo sapiens] [Reaction:2314686] ASA- acetylates PTGS2 [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200250] R-HSA-2161907.5
summation	[Summation:2162012] Arachidonate 5-lipoxygenase (ALOX5) converts 15R-hydro-eicos...
(hasEvent)	[Pathway:2142700] Biosynthesis of Lipoxins (LX) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778806] Update Tracker - [Reaction:2161907] ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 - v67:[addInput] [_UpdateTracker:9779779] Update Tracker - [Reaction:2161907] ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 - v64:[modifyText]
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