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Details on Person Arachidonate is epoxidated to 8,9-EET by CYP(5)

Class:Id	Reaction:2161899
_displayName	Arachidonate is epoxidated to 8,9-EET by CYP(5)
_doRelease	TRUE
_timestamp	2024-08-02 18:54:35
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161882] monooxygenase activity of CYP(5) [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915974] RHEA:64985
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:29768] AA [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
isChimeric	FALSE
literatureReference	[LiteratureReference:2162004] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 [LiteratureReference:2161833] Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS [LiteratureReference:2161944] Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes [LiteratureReference:215077] Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201180] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2308243] D'Eustachio, P, 2012-06-04 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586591] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915999] D'Eustachio, Peter, 2024-07-19 [InstanceEdit:9917185] D'Eustachio, Peter, 2024-07-31 [InstanceEdit:9917368] D'Eustachio, Peter, 2024-08-02
name	Arachidonate is epoxidated to 8,9-EET by CYP(5) 5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:2142662] 8,9-EET [cytosol]
precedingEvent	[Reaction:428990] SLC27A1 transports arachidonate across the ER membrane [Homo sapiens] [Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200662] R-HSA-2161899.4
structureModified	[InstanceEdit:9915999] D'Eustachio, Peter, 2024-07-19
summation	[Summation:2161777] Several cytochrome P450s (CYPs) convert arachidonate to 8,9-...
(hasEvent)	[Pathway:2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) [Homo sapiens]
(precedingEvent)	[Reaction:9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919339] Update Tracker - [Reaction:2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - v90:[add_removeOutput, modifyText]
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