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Details on Person 5S-HpETE is reduced to 5S-HETE by GPX1

Class:Id	Reaction:2161896
_displayName	5S-HpETE is reduced to 5S-HETE by GPX1
_doRelease	TRUE
_timestamp	2024-07-17 22:41:17
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161894] glutathione peroxidase activity of GPX1 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915893] RHEA:48621
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:266010] 5S-HpETE [cytosol] [SimpleEntity:29450] GSH [cytosol] [SimpleEntity:29450] GSH [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2162058] Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2629680] D'Eustachio, P, 2012-11-20 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915896] D'Eustachio, Peter, 2024-07-17
name	5S-HpETE is reduced to 5S-HETE by GPX1 (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
output	[SimpleEntity:2142733] 5S-HETE [cytosol] [SimpleEntity:111745] GSSG [cytosol] [SimpleEntity:29356] H2O [cytosol]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49130] Oryctolagus cuniculus
stableIdentifier	[StableIdentifier:3200281] R-OCU-2161896.4
summation	[Summation:2161879] The cytosol of rabbit lung alveolar macrophages contains a h...
(hasEvent)	[Pathway:2142661] Arachidonic acid Metabolism pathway - Inferred Events
(inferredFrom)	[Reaction:2161946] 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 [Homo sapiens]
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