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Details on Person 15k-LXA4 is reduced to dhk-LXA4 by PTGR1

Class:Id	Reaction:2161844
_displayName	15k-LXA4 is reduced to dhk-LXA4 by PTGR1
_doRelease	TRUE
_timestamp	2024-08-02 19:04:44
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161822] 13-lipoxin reductase activity of PTGR1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9916389] 13-lipoxin reductase activity of PTGR1 [cytosol] Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9916407] RHEA:41593
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
inferredFrom	[Reaction:2161847] 15k-LXA4 is reduced to dhk-LXA4 by PTGR1 [Sus scrofa]
input	[SimpleEntity:2142761] 15k-LXA4 [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:73473] NADH [cytosol]
internalReviewed	[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
isChimeric	FALSE
literatureReference	[LiteratureReference:2161669] cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase [LiteratureReference:2161884] Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586590] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9037802] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9916393] D'Eustachio, Peter, 2024-07-24 [InstanceEdit:9917369] D'Eustachio, Peter, 2024-08-02
name	15k-LXA4 is reduced to dhk-LXA4 by PTGR1 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)
output	[SimpleEntity:2142690] dhk-LXA4 [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
precedingEvent	[Reaction:2161779] LXA4 is oxidised to 15k-LXA4 by HPGD [Homo sapiens] [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4 [Homo sapiens] [Reaction:2161917] ALOX5 oxidises 15S-HpETE to LXA4/B4 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200236] R-HSA-2161844.5
structureModified	[InstanceEdit:9916393] D'Eustachio, Peter, 2024-07-24
summation	[Summation:2161913] Prostaglandin reductase 1 (PTGR1) aka LTB4DH, a 15-oxoprosta...
(hasEvent)	[Pathway:2142700] Biosynthesis of Lipoxins (LX) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919436] Update Tracker - [Reaction:2161844] 15k-LXA4 is reduced to dhk-LXA4 by PTGR1 - v90:[add_removeInput, add_removeOutput]
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