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Details on Person Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

Class:Id	LiteratureReference:216183
_displayName	Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
_timestamp	2008-03-11 15:49:55
author	[Person:216122] Denef, N [Person:216203] Neub�ser, D [Person:216103] Perez, L [Person:216201] Cohen, SM
created	[InstanceEdit:216199] Williams, MG, 2008-03-11 15:41:17
journal	Cell
pages	521-31
pubMedIdentifier	10966113
title	Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
volume	102
year	2000
(literatureReference)	[Summation:445099] Smoothened (Smo) is usually classified with family B GPCRs b... [Reaction:216202] Phosphorylated SMO changes conformation and is activated [Drosophila melanogaster] [BlackBoxEvent:5610763] PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal [Homo sapiens] [Reaction:5632646] SMURF1/2 bind PTCH1 [Homo sapiens] [BlackBoxEvent:5632668] SMO translocates to the cilium [Homo sapiens] [BlackBoxEvent:5632677] PTCH is internalized [Homo sapiens] [Pathway:5635838] Activation of SMO [Homo sapiens]
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