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Details on Person Arachidonate is hydroxylated to 19-HETE by CYP(2)

Class:Id	Reaction:2161814
_displayName	Arachidonate is hydroxylated to 19-HETE by CYP(2)
_doRelease	TRUE
_timestamp	2024-07-31 13:54:02
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2162026] monooxygenase activity of CYP(2) [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915972] RHEA:39760
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:140356] AA [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161920] Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes [LiteratureReference:2161835] Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension [LiteratureReference:216555] CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids [LiteratureReference:2162004] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2303722] D'Eustachio, P, 2012-06-04 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586591] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915999] D'Eustachio, Peter, 2024-07-19 [InstanceEdit:9917185] D'Eustachio, Peter, 2024-07-31
name	Arachidonate is hydroxylated to 19-HETE by CYP(2) (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:2142836] 19-HETE [endoplasmic reticulum lumen] [SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
precedingEvent	[Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens] [Reaction:111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200151] R-HSA-2161814.4
summation	[Summation:2161906] Several cytochrome P450s (CYPs) convert arachidonate to 19-h...
(hasEvent)	[Pathway:2142816] Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919408] Update Tracker - [Reaction:2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - v90:[modifyText]
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