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Details on Person 15S-HETE is oxidised to 15-oxoETE by 15-HEDH

Class:Id	Reaction:2161789
_displayName	15S-HETE is oxidised to 15-oxoETE by 15-HEDH
_doRelease	TRUE
_timestamp	2024-07-17 22:41:10
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161741] 15-hydroxyicosatetraenoate dehydrogenase activity of 15-HEDH [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915902] RHEA:23260 [DatabaseIdentifier:9915886] RHEA:23264
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:2142707] 15S-HETE [cytosol] [DefinedSet:428218] NAD(P)+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2162040] Expression of 15-lipoxygenase type-1 in human mast cells
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2308252] D'Eustachio, P, 2012-06-05 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586590] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915896] D'Eustachio, Peter, 2024-07-17
name	15S-HETE is oxidised to 15-oxoETE by 15-HEDH (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(P)(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NAD(P)H
output	[SimpleEntity:2142747] 15-oxoETE [cytosol] [DefinedSet:428206] NAD(P)H [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:2161791] 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 [Homo sapiens] [Reaction:2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200711] R-HSA-2161789.4
summation	[Summation:2161977] A 15-hydroxy-eicosatetraenoic acid dehydrogenase (15-HEDH) o...
(hasEvent)	[Pathway:2142770] Synthesis of 15-eicosatetraenoic acid derivatives [Homo sapiens]
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