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Details on Person ALOX12 oxidises LTA4 to LXA4

Class:Id	Reaction:2161775
_displayName	ALOX12 oxidises LTA4 to LXA4
_doRelease	TRUE
_timestamp	2024-08-21 18:38:16
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161800] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9916378] RHEA:48585
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:9032038] LTA4 [cytosol] [SimpleEntity:9032038] LTA4 [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
isChimeric	FALSE
literatureReference	[LiteratureReference:2161873] Lipoxin synthase activity of human platelet 12-lipoxygenase [LiteratureReference:2162054] Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro [LiteratureReference:2161812] Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201179] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:2586592] D'Eustachio, P, 2012-11-15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9032042] Jassal, Bijay, 2017-12-05 [InstanceEdit:9037809] Jassal, Bijay, 2018-02-21 [InstanceEdit:9628713] Jassal, Bijay, 2018-11-12 [InstanceEdit:9628714] Jassal, Bijay, 2018-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9916393] D'Eustachio, Peter, 2024-07-24 [InstanceEdit:9917369] D'Eustachio, Peter, 2024-08-02 [InstanceEdit:9919252] D'Eustachio, Peter, 2024-08-19 [InstanceEdit:9919317] D'Eustachio, Peter, 2024-08-21
name	ALOX12 oxidises LTA4 to LXA4 2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4
output	[SimpleEntity:2161759] LXA4 [cytosol] [SimpleEntity:2161759] LXA4 [cytosol]
precedingEvent	[BlackBoxEvent:9032036] LTA4 translocates from neutrophil cytosol to platelet cytosol [Homo sapiens] [Reaction:266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-03-13
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200594] R-HSA-2161775.6
structureModified	[InstanceEdit:9916393] D'Eustachio, Peter, 2024-07-24
summation	[Summation:2162021] Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses th...
(hasEvent)	[Pathway:2142700] Biosynthesis of Lipoxins (LX) [Homo sapiens]
(precedingEvent)	[Reaction:2161779] LXA4 is oxidised to 15k-LXA4 by HPGD [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778825] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4/B4 - v67:[addInput] [_UpdateTracker:9779924] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4/B4 - v64:[add_removeInput] [_UpdateTracker:9919345] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4 - v90:[add_removeOutput, modifyText, removeInput]
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