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Details on Person PGE2 is converted to PGF2a by CBR1

Class:Id	Reaction:2161651
_displayName	PGE2 is converted to PGF2a by CBR1
_doRelease	TRUE
_timestamp	2024-07-12 21:31:40
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161655] prostaglandin E2 9-reductase activity of CBR1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9915621] prostaglandin-E2 9-reductase activity of CBR1 [cytosol] Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161624] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915623] RHEA:24510
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:265287] PGE2 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161616] Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase [LiteratureReference:2161709] Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201174] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2569041] D'Eustachio, P, 2012-11-10 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915663] D'Eustachio, Peter, 2024-07-12
name	PGE2 is converted to PGF2a by CBR1 H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha
output	[SimpleEntity:879535] PGF2a [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200475] R-HSA-2161651.4
summation	[Summation:2161561] Carbonyl reductase (CBR1) aka prostaglandin 9-keto reductase...
(hasEvent)	[Pathway:2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) [Homo sapiens]
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No pathways have been reviewed or authored by PGE2 is converted to PGF2a by CBR1 (2161651)