Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PGH2 is reduced to PGF2a by AKR1C3

Class:Id	Reaction:2161549
_displayName	PGH2 is reduced to PGF2a by AKR1C3
_doRelease	TRUE
_timestamp	2024-07-12 21:31:43
authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161558] prostaglandin H2 endoperoxidase reductase activity of AKR1C3 [cytosol]
catalystActivityReference	[CatalystActivityReference:9915642] prostaglandin H2 endoperoxidase reductase activity of AKR1C3 [cytosol] Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161550] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915645] RHEA:45314
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
input	[SimpleEntity:265283] PGH2 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161552] cDNA cloning, expression and characterization of human prostaglandin F synthase [LiteratureReference:2161547] Crystal structure of human prostaglandin F synthase (AKR1C3) [LiteratureReference:2161559] Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost
modified	[InstanceEdit:2162189] Williams, MG, 2012-03-15 [InstanceEdit:2201174] Williams, MG, 2012-04-17 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2303722] D'Eustachio, P, 2012-06-04 [InstanceEdit:2569041] D'Eustachio, P, 2012-11-10 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915663] D'Eustachio, Peter, 2024-07-12
name	PGH2 is reduced to PGF2a by AKR1C3 H(+) + NADPH + prostaglandin H2 => NADP(+) + prostaglandin F2alpha
output	[SimpleEntity:879535] PGF2a [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[BlackBoxEvent:2299725] PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol [Homo sapiens] [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 [Homo sapiens] [Reaction:2309773] PGG2 is reduced to PGH2 by PTGS2 [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200550] R-HSA-2161549.4
summation	[Summation:2161555] Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is ...
(hasEvent)	[Pathway:2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by PGH2 is reduced to PGF2a by AKR1C3 (2161549)