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Details on Person Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity

Class:IdLiteratureReference:2161101
_displayNamePhosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity
_timestamp2012-03-07 16:14:18
author[Person:109598] Miller, WH
[Person:2161094] Daluge, SM
[Person:109371] Garvey, EP
[Person:2161100] Hopkins, S
[Person:177419] Reardon, JE
[Person:2161086] Boyd, FL
[Person:109596] Miller, RL
created[InstanceEdit:2161087] D'Eustachio, P, 2012-03-07
journalJ Biol Chem
pages21220-4
pubMedIdentifier1383219
titlePhosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity
volume267
year1992
(literatureReference)[CatalystActivityReference:9643257] nucleoside diphosphate kinase activity of Pck1 [cytosol] Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity
[CatalystActivityReference:9643333] nucleoside monophosphate kinase activity of GUK1 [cytosol] Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity
[RegulationReference:9690703] Negative regulation by 'carbovir triphosphate [cytosol]' A review of the pharmacokinetics of abacavir
[Reaction:2162066] carbovir + IMP => carbovir monophosphate + inosine [Homo sapiens]
[Reaction:2162073] carbovir monophosphate + ATP => carbovir diphosphate + ADP [Sus scrofa]
[Reaction:2162084] carbovir diphosphate + ATP => carbovir triphosphate + ADP [Rattus norvegicus]
[Reaction:2162092] carbovir monophosphate + ATP => carbovir diphosphate + ADP [Homo sapiens]
[Reaction:2162096] carbovir diphosphate + ATP => carbovir triphosphate + ADP [Homo sapiens]
[BlackBoxEvent:9754978] Unknown kinase phosphorylates RBV-MP [Homo sapiens]
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