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Details on Person VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8

Class:Id	Reaction:216076
_displayName	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8
_doRelease	TRUE
_timestamp	2013-08-15 16:18:48
authored	[InstanceEdit:266384] Geiger, B, Horwitz, R, 2008-05-07 08:30:32
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:216075] Garapati, P V, 2008-03-11 10:17:01
edited	[InstanceEdit:216084] Garapati, P V, 2008-03-11 10:20:45
input	[EntityWithAccessionedSequence:215971] VTN [extracellular region] [Homo sapiens] [DefinedSet:4205072] Integrin alphaVbeta3, 5, 8 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:215781] The alpha v beta 3 integrin "vitronectin receptor" [LiteratureReference:266117] Involvement of alpha(v)beta3 integrins in osteoclast function [LiteratureReference:2396446] The alpha v beta 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin [LiteratureReference:215862] The alphavbeta5 integrin functions as an endocytic receptor for vitronectin [LiteratureReference:216309] The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin [LiteratureReference:216310] Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain
modified	[InstanceEdit:266120] Garapati, P V, 2008-04-22 13:11:32 [InstanceEdit:266361] Gopinathrao, G, 2008-05-06 15:10:28 [InstanceEdit:266362] Gopinathrao, G, 2008-05-06 18:16:31 [InstanceEdit:266419] Garapati, P V, 2008-05-07 10:51:12 [InstanceEdit:353634] Garapati, P V, 2008-06-13 10:17:32 [InstanceEdit:920202] Garapati, P V, 2010-08-04 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:4205070] Jupe, S, 2013-08-15 [InstanceEdit:4210796] Jupe, S, 2013-08-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8
output	[Complex:216017] VTN:Integrin alphaVbeta3, 5, 8 [plasma membrane] [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:266386] Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:4090280] Jupe, S, 2013-08-13
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360356] R-HSA-216076.2
summation	[Summation:266098] Integrin alphaVbeta3 is highly expressed on osteoclasts, bon...
(hasEvent)	[Pathway:216083] Integrin cell surface interactions [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787119] Update Tracker - [Reaction:216076] VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 - v46:[addLiteratureReference, add_removeInput, modifyText]
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