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Details on Person Retinoic acid (RA) is a biologically active analogue of vita...
| Class:Id | Summation:215595 |
|---|---|
| _displayName | Retinoic acid (RA) is a biologically active analogue of vita... |
| _timestamp | 2014-09-08 17:19:45 |
| created | [InstanceEdit:215585] Jassal, B, 2008-03-06 14:26:56 |
| modified | [InstanceEdit:215652] Jassal, B, 2008-03-06 14:28:58 [InstanceEdit:5545499] Jassal, Bijay, 2014-05-22 [InstanceEdit:5622022] Jassal, Bijay, 2014-09-08 |
| text | Retinoic acid (RA) is a biologically active analogue of vitamin A (retinol). RA plays an important role in regulating cell growth and differentiation.CYP26A1 is involved in the metabolic breakdown of RA by 4-hydroxylation. CYP26A1-mediated 4-hydroxylation is specific for all-trans-RA but not for the isomers 13-cis-RA and 9-cis-RA (Sonneveld et al. 1998). CYP26B1 can also deactivate all-trans-retinoic acid by 4-hydroxylation. High expression levels in the cerebellum and pons of human brain suggests a protective role of specific tissues against retinoid damage (White et al. 2000). |
| (summation) | [Reaction:212007] CYP26A1,B1 4-hydroxylate atRA [Homo sapiens] |
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