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Details on Person Phosphorylated CACT is degraded in the cytosol

Class:Id	BlackBoxEvent:214871
_displayName	Phosphorylated CACT is degraded in the cytosol
_doRelease	TRUE
_timestamp	2021-08-03 16:31:05
authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
catalystActivity	[CatalystActivity:208900] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:214841] Williams, MG, 2008-02-26 12:28:44
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:358168] /figures/DrosTollImdC21.jpg
input	[Complex:214741] Phospho DL/DIF dimer:Phospho CACT [cytosol] [Drosophila melanogaster]
literatureReference	[LiteratureReference:214877] Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses [LiteratureReference:208075] A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo [LiteratureReference:214855] Cactus protein degradation mediates Drosophila dorsal-ventral signaling [LiteratureReference:214846] A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila [LiteratureReference:214843] In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila [LiteratureReference:208375] Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP
modified	[InstanceEdit:358174] Williams, MG, 2008-06-19 09:35:28 [InstanceEdit:372363] Williams, MG, 2008-06-23 10:13:54 [InstanceEdit:386962] Williams, MG, 2008-11-27 15:15:51 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9749431] Matthews, Lisa, 2021-08-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated CACT is degraded in the cytosol
output	[DefinedSet:214728] Phospho DL/DIF dimer [cytosol] [Drosophila melanogaster]
precedingEvent	[Reaction:214864] Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' [Drosophila melanogaster] [Reaction:214860] CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' [Drosophila melanogaster] [Reaction:214847] Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' [Drosophila melanogaster] [Reaction:214845] CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8911345] R-DME-214871.5
summation	[Summation:214264] In humans, the Cactus (CACT) orthologue IkappaB is polyubiqu...
(hasEvent)	[Pathway:209406] Degradation of NF-kappa-B inhibitor, CACT [Drosophila melanogaster]
(precedingEvent)	[Reaction:209295] Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus [Drosophila melanogaster]
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