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Query author contributions in Reactome
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Details on Person UniProt:Q9VJN5 wek
Class:Id
ReferenceGeneProduct:214757
_chainChangeLog
chain:1-470 added on Fri February 6 2015
_displayName
UniProt:Q9VJN5 wek
_timestamp
2023-11-03 15:42:18
chain
chain:1-470
checksum
E8B2E991E3657A73
comment
FUNCTION Acts as an adapter to assemble/stabilize a Toll/wek/Myd88/tube complex; required for efficient recruitment of Myd88 to Toll. Dispensable for innate immune response; plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi. Involved in dorsoventral axis determination.SUBUNIT Homodimer. Interacts with Myd88 and Toll.SUBCELLULAR LOCATION Localizes to the plasma membrane in embryos when bound to Myd88.
