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Details on Person Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

Class:Id	Reaction:214405
_displayName	Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'
_doRelease	TRUE
_timestamp	2018-03-09 00:11:38
authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:214403] Williams, MG, 2008-02-26 12:03:36
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:358128] /figures/DrosTollImdC34.jpg
inferredFrom	[Reaction:83650] FasL:Fas binds FADD [Homo sapiens] [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 [Homo sapiens]
input	[Polymer:354246] Mono PGN:PGRP-LE oligomer [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:206183] IMD [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:205887] BG4 [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:205876] DREDD [cytosol] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208161] Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins [LiteratureReference:208221] PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan [LiteratureReference:208229] The Drosophila immune defense against gram-negative infection requires the death protein dFADD [LiteratureReference:208334] dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD
modified	[InstanceEdit:354256] Williams, MG, 2008-06-17 10:08:33 [InstanceEdit:358126] Williams, MG, 2008-06-19 09:29:42 [InstanceEdit:372363] Williams, MG, 2008-06-23 10:13:54 [InstanceEdit:386957] Williams, MG, 2008-11-27 14:37:44 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024533] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'
output	[Complex:214404] Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD [cytosol] [Drosophila melanogaster]
precedingEvent	[BlackBoxEvent:214395] Monomeric PGN bound PGRP-LE oligomerises in the cytosol [Drosophila melanogaster] [Reaction:214410] Monomeric PGN binds to PGRP-LE in the cytosol [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8905117] R-DME-214405.4
summation	[Summation:214270] Upon monomeric peptidoglycan (PGN) binding and receptor mult...
(hasEvent)	[Pathway:214397] Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' [Drosophila melanogaster]
(precedingEvent)	[Reaction:214418] REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' [Drosophila melanogaster]
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