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Details on Person Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

Class:Id	Reaction:214393
_displayName	Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'
_doRelease	TRUE
_timestamp	2018-03-09 00:16:59
authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
catalystActivity	[CatalystActivity:208875] cysteine-type endopeptidase activity of DREDD [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:214403] Williams, MG, 2008-02-26 12:03:36
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:358170] /figures/DrosTollImdC43.jpg
input	[Complex:214409] Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD:Phospho REL [cytosol] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208086] Caspase-mediated processing of the Drosophila NF-kappaB factor Relish
modified	[InstanceEdit:354276] Williams, MG, 2008-06-17 10:10:07 [InstanceEdit:358174] Williams, MG, 2008-06-19 09:35:28 [InstanceEdit:372363] Williams, MG, 2008-06-23 10:13:54 [InstanceEdit:386962] Williams, MG, 2008-11-27 15:15:51 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'
output	[Complex:214404] Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:205709] Phospho REL-49 [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:354270] Phospho REL-68 [cytosol] [Drosophila melanogaster]
precedingEvent	[Reaction:214398] Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' [Drosophila melanogaster] [Reaction:209240] Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5 [Drosophila melanogaster] [Reaction:214418] REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8926960] R-DME-214393.4
summation	[Summation:206392] Phosphorylated Relish (REL) is endoproteolytically cleaved b...
(hasEvent)	[Pathway:214416] Phosphorylated REL is cleaved by and dissociates from DREDD [Drosophila melanogaster]
(precedingEvent)	[Reaction:209309] Phosphorylated REL-68 transports from the cytosol to the nucleus [Drosophila melanogaster]
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