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Details on Person In humans, the Cactus (CACT) orthologue IkappaB is polyubiqu...
| Class:Id | Summation:214264 |
|---|---|
| _displayName | In humans, the Cactus (CACT) orthologue IkappaB is polyubiqu... |
| _timestamp | 2008-06-19 09:32:31 |
| created | [InstanceEdit:214267] Williams, MG, 2008-02-26 11:58:01 |
| modified | [InstanceEdit:358146] Williams, MG, 2008-06-19 09:32:34 |
| text | In humans, the Cactus (CACT) orthologue IkappaB is polyubiquitinated by the beta-TrCP E3 ubiquitin ligase containing complex. This marks it for degradation by the 26S proteosome. It is believed that CACT is degraded in a similar manner, however, a Drosophila E3 ubiquitin ligase that acts in the Toll pathway has yet to be identified. The obvious candidate, the closest beta-TrCP orthologue Slimb (SLMB) has produced contradictory evidence on whether it participates in the Toll pathway (Spencer et al., 1999; Leulier et al., 2003). |
| (summation) | [BlackBoxEvent:214871] Phosphorylated CACT is degraded in the cytosol [Drosophila melanogaster] |
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No pathways have been reviewed or authored by In humans, the Cactus (CACT) orthologue IkappaB is polyubiqu... (214264)
