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Details on Person Caspase-activated PAK-2 phosphorylates Mnk1 at Ser(27)

Class:IdReaction:213331
_displayNameCaspase-activated PAK-2 phosphorylates Mnk1 at Ser(27)
_doReleaseFALSE
_timestamp2024-07-16 19:49:24
authored[InstanceEdit:211578] Traugh, JA, Jung, JH, 2008-02-06 09:37:35
catalystActivity[CatalystActivity:266146] protein serine/threonine kinase activity of phospho-PAK-2p34 (Thr 402) [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:213332] Matthews, L, 2008-02-25 13:42:02
edited[InstanceEdit:211619] Matthews, L, 2008-02-03 20:50:13
input[SimpleEntity:113592] ATP [cytosol]
[EntityWithAccessionedSequence:163172] Mm:Mnk1 protein [cytosol] [Mus musculus]
isChimericTRUE
literatureReference[LiteratureReference:211657] Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk
modified[InstanceEdit:213333] Matthews, L, 2008-02-25 13:42:37
[InstanceEdit:266145] Matthews, L, 2008-04-25 11:29:13
[InstanceEdit:349502] Matthews, L, 2008-05-08 00:39:03
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9620036] Matthews, Lisa, 2018-09-19
[InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
nameCaspase-activated PAK-2 phosphorylates Mnk1 at Ser(27)
output[SimpleEntity:29370] ADP [cytosol]
[EntityWithAccessionedSequence:213330] phospho-Mnk1 (ser-27) [cytosol] [Mus musculus]
reviewed[InstanceEdit:213027] Jakobi, R, 2008-02-25 02:02:42
species[Species:48892] Mus musculus
[Species:49130] Oryctolagus cuniculus
stableIdentifier[StableIdentifier:8918009] R-NUL-213331.1
summation[Summation:211663] Mnk1 is phosphorylated by PAK-2 at Ser-27 (Orton et al.,2004...
(hasEvent)[Pathway:266147] Down-regulation of translation initiation in apoptosis by Pak-2-mediated phosphorylation of Mnk1 [Mus musculus]
(inferredFrom)[Reaction:211666] Caspase-activated PAK-2 phosphorylates Mnk1 at Ser(27) [Homo sapiens]
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