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Details on Person UniProt:Q9NPJ6 MED4

Class:Id	ReferenceGeneProduct:213239
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-270 added on Fri February 6 2015;initiator methionine:1 for 213239 removed on Fri Nov 03 2023;initiator methionine: for 213239 added on Fri Nov 03 2023;initiator methionine: for 213239 removed on Fri Aug 15 2025;initiator methionine:1 for 213239 added on Fri Aug 15 2025
_displayName	UniProt:Q9NPJ6 MED4
_timestamp	2025-08-15 21:31:39
chain	initiator methionine:1 chain:2-270
checksum	05641357EBFA85F4
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.INTERACTION Belongs to the Mediator complex subunit 4 family.
created	[InstanceEdit:213238] Caudy, M, 2008-02-22 09:42:02
description	recommendedName: Mediator of RNA polymerase II transcription subunit 4 alternativeName: Activator-recruited cofactor 36 kDa component shortName: ARC36 alternativeName: Mediator complex subunit 4 alternativeName: TRAP/SMCC/PC2 subunit p36 subunit alternativeName: Vitamin D3 receptor-interacting protein complex 36 kDa component shortName: DRIP36
geneName	MED4 ARC36 DRIP36 VDRIP HSPC126
identifier	Q9NPJ6
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Activator Alternative splicing Coiled coil Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	MED4
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8957460] ENSEMBL:ENSG00000136146 MED4 [Homo sapiens]
secondaryIdentifier	MED4_HUMAN B4DX67 Q53GB4 Q53H68 Q5T912 Q6FHC4 Q6IA79 Q9BS95 Q9NYR5
sequenceLength	270
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8970145] UniProt:Q9NPJ6-1 MED4 [Homo sapiens] [ReferenceIsoform:8970146] UniProt:Q9NPJ6-2 MED4 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:350263] MED4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8958540] MED4 [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9NPJ6 MED4 (213239)