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Details on Person Cleavage of C5 by C5 convertases

Class:Id	Reaction:2132278
_displayName	Cleavage of C5 by C5 convertases
_doRelease	TRUE
_timestamp	2014-11-20 02:42:16
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
catalystActivity	[CatalystActivity:2132282] serine-type endopeptidase activity of C5 convertases [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132292] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
inferredFrom	[Reaction:173680] Activation of C5 [Homo sapiens]
input	[Complex:2132280] complement factor C5 [extracellular region] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:173702] Formation of high affinity C5 convertase of the classical pathway of complement [LiteratureReference:2173456] Genomic view of the evolution of the complement system
modified	[InstanceEdit:2173593] Shamovsky, V, 2012-03-30 [InstanceEdit:2530595] Shamovsky, V, 2012-10-17 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465607] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of C5 by C5 convertases
output	[EntityWithAccessionedSequence:2132257] C5a [extracellular region] [Gallus gallus] [Complex:2132150] C5b [extracellular region] [Gallus gallus]
precedingEvent	[Reaction:2132264] Formation of alternate C5 convertase [Gallus gallus] [Reaction:2132085] Cleavage of C3 by surface-bound C3 convertases [Gallus gallus] [Reaction:2132074] Cleavage of surface-bound factor B [Gallus gallus] [Reaction:2132269] Formation of classical C5 convertase [Gallus gallus] [Reaction:2132085] Cleavage of C3 by surface-bound C3 convertases [Gallus gallus] [Reaction:2132222] Cleavage of factor B to form classical C3 convertase [Gallus gallus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5644618] R-GGA-2132278.2
summation	[Summation:2173390] C5 convertases are serine proteases that cleave complement C...
(hasEvent)	[Pathway:2132285] Complement Cascade [Gallus gallus]
(precedingEvent)	[Reaction:2132284] Formation of C5b:C6 [Gallus gallus] [Reaction:2173318] C5a anaphylatoxin binds C5a receptor [Gallus gallus]
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No pathways have been reviewed or authored by Cleavage of C5 by C5 convertases (2132278)