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Details on Person Complement factor I inactivates C3b

Class:Id	Reaction:2132276
_displayName	Complement factor I inactivates C3b
_doRelease	TRUE
_timestamp	2016-02-02 16:10:01
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
catalystActivity	[CatalystActivity:2132268] serine-type endopeptidase activity of CFI [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2132292] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
inferredFrom	[Reaction:976810] Complement factor I binds to extracellular Factor H:C3b [Homo sapiens]
input	[Complex:2132240] CFH:C3b [extracellular region] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2409064] Mapping of the sites responsible for factor I-cofactor activity for cleavage of C3b and C4b on human C4b-binding protein (C4bp) by deletion mutagenesis [LiteratureReference:2409058] Analysis of binding sites on complement factor I that are required for its activity [LiteratureReference:977617] Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46) [LiteratureReference:977604] Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity
modified	[InstanceEdit:2314543] Shamovsky, V, 2012-06-07 [InstanceEdit:2409072] Shamovsky, V, 2012-07-17 [InstanceEdit:2530595] Shamovsky, V, 2012-10-17 [InstanceEdit:2859048] Shamovsky, V, 2012-12-19 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465608] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:8855193] Shamovsky, Veronica, 2016-02-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Complement factor I inactivates C3b
output	[Complex:2132290] iC3b [extracellular region] [Gallus gallus] [EntityWithAccessionedSequence:2132239] C3f [extracellular region] [Gallus gallus] [EntityWithAccessionedSequence:2132241] CFH [extracellular region] [Gallus gallus]
precedingEvent	[Reaction:2132261] Complement factor H binds to C3b [Gallus gallus] [Reaction:2173323] Cleavage of C3 by fluid-phase C3i:factor B [Gallus gallus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5644202] R-GGA-2132276.3
summation	[Summation:2859022] Complement factor I (CFI) is a serine protease that inhibits...
(hasEvent)	[Pathway:2132281] Regulation of complement cascades [Gallus gallus]
(precedingEvent)	[BlackBoxEvent:2530565] iC3b proteolysis [Gallus gallus]
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No pathways have been reviewed or authored by Complement factor I inactivates C3b (2132276)