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Details on Person Formation of classical C5 convertase

Class:Id	Reaction:2132269
_displayName	Formation of classical C5 convertase
_doRelease	TRUE
_timestamp	2014-11-20 02:52:59
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132292] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
inferredFrom	[Reaction:173636] Formation of classic pathway C5 convertase [Homo sapiens]
input	[Complex:2132052] C4b:factor Bb [plasma membrane] [Gallus gallus] [Complex:2132189] C3b [extracellular region] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:173702] Formation of high affinity C5 convertase of the classical pathway of complement
modified	[InstanceEdit:2314531] Shamovsky, V, 2012-06-07 [InstanceEdit:2530595] Shamovsky, V, 2012-10-17 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465608] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of classical C5 convertase
output	[Complex:2132130] C4b:factor B:C3b [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:2132085] Cleavage of C3 by surface-bound C3 convertases [Gallus gallus] [Reaction:2132222] Cleavage of factor B to form classical C3 convertase [Gallus gallus] [Reaction:2132100] Fluid-phase proteolytic cleavage of factor B [Gallus gallus] [Reaction:2132074] Cleavage of surface-bound factor B [Gallus gallus] [Reaction:2132222] Cleavage of factor B to form classical C3 convertase [Gallus gallus] [Reaction:2132065] C1r activates C1s component within C1 complement complex [Gallus gallus] [Reaction:2132206] MASPs activation [Gallus gallus] [Reaction:2132096] Formation of C4b:factor B complex [Gallus gallus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5645039] R-GGA-2132269.2
summation	[Summation:2173491] In mammals, C3b binds covalently to a specific site on the C...
(hasEvent)	[Pathway:2132285] Complement Cascade [Gallus gallus]
(precedingEvent)	[Reaction:2132278] Cleavage of C5 by C5 convertases [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9777787] Update Tracker - [Reaction:2132269] Formation of classical C5 convertase - v69:[modifyText]
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