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Details on Person MASPs activation

Class:Id	Reaction:2132206
_displayName	MASPs activation
_doRelease	TRUE
_timestamp	2014-11-20 02:48:10
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
entityOnOtherCell	[DefinedSet:2173559] surface-bound lectins:Ca2+:MASPs [plasma membrane] [Gallus gallus] [DefinedSet:2132097] surface-bound lectin:Ca2+:activated MASPs [plasma membrane] [Gallus gallus]
input	[DefinedSet:2173559] surface-bound lectins:Ca2+:MASPs [plasma membrane] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2173527] Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway [LiteratureReference:183107] Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases [LiteratureReference:2173402] Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2 [LiteratureReference:2173439] Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2 [LiteratureReference:2173434] Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins [LiteratureReference:2173421] Composition of the lectin pathway of complement in Gallus gallus: absence of mannan-binding lectin-associated serine protease-1 in birds [LiteratureReference:2859033] Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2
modified	[InstanceEdit:2314526] Shamovsky, V, 2012-06-07 [InstanceEdit:2859048] Shamovsky, V, 2012-12-19 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465608] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MASPs activation
output	[DefinedSet:2132097] surface-bound lectin:Ca2+:activated MASPs [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:2132187] MBL or ficolin binds an oligosaccharide pattern on the target cell surface [Gallus gallus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5644847] R-GGA-2132206.2
summation	[Summation:2173512] MBL and ficolins circulate as complexes with MBL-associated ...
(hasEvent)	[Pathway:2132270] Lectin-mediated initiation of complement cascade [Gallus gallus]
(precedingEvent)	[Reaction:2132222] Cleavage of factor B to form classical C3 convertase [Gallus gallus] [BlackBoxEvent:2132233] Proteolytic cleavage of complement factor C4 [Gallus gallus]
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No pathways have been reviewed or authored by MASPs activation (2132206)