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Details on Person Opsonization with C3b or C4b

Class:Id	BlackBoxEvent:2132201
_displayName	Opsonization with C3b or C4b
_doRelease	TRUE
_timestamp	2014-11-20 02:43:02
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
inferredFrom	[Reaction:981539] C3b binds to cell surface [Homo sapiens] [Reaction:981713] C4b binds to cell surface [Homo sapiens]
input	[DefinedSet:2132216] C3b/C4b [extracellular region] [Gallus gallus] [OtherEntity:2132109] Cell-surface carbohydrates [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:2314656] Fibronectin-enhanced phagocytosis of an alternative pathway activator by human culture-derived macrophages is mediated by the C4b/C3b complement receptor (CR1) [LiteratureReference:2314649] Kinetic studies of phagocytosis. III. The complement-dependent opsonic and anti-opsonic effects of normal and sle sera [LiteratureReference:2314676] The binding of immune complexes by the erythrocyte complement receptor 1 (CR1) [LiteratureReference:2314663] Complement-opsonized IgG antibody/dsDNA immune complexes bind to CR1 clusters on isolated human erythrocytes [LiteratureReference:2314654] Mechanism of transfer of immune complexes from red blood cell CR1 to monocytes
modified	[InstanceEdit:2314526] Shamovsky, V, 2012-06-07 [InstanceEdit:2314677] Shamovsky, V, 2012-06-07 [InstanceEdit:2530595] Shamovsky, V, 2012-10-17 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465608] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Opsonization with C3b or C4b
output	[DefinedSet:2132152] C3b/C4b [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:2132085] Cleavage of C3 by surface-bound C3 convertases [Gallus gallus] [Reaction:2132222] Cleavage of factor B to form classical C3 convertase [Gallus gallus] [Reaction:2132100] Fluid-phase proteolytic cleavage of factor B [Gallus gallus] [Reaction:2132074] Cleavage of surface-bound factor B [Gallus gallus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5644641] R-GGA-2132201.2
summation	[Summation:2314463] C4b and C3b are opsonins, which are able to bind covalently ...
(hasEvent)	[Pathway:2132285] Complement Cascade [Gallus gallus]
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No pathways have been reviewed or authored by Opsonization with C3b or C4b (2132201)