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Details on Person Formation of C4b:factor B complex

Class:Id	Reaction:2132096
_displayName	Formation of C4b:factor B complex
_doRelease	TRUE
_timestamp	2019-05-08 23:35:31
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
inferredFrom	[Reaction:166795] Formation of Classical C3 convertase (C4b:C2a complex) [Homo sapiens]
input	[Complex:2132117] C4b [plasma membrane] [Gallus gallus] [EntityWithAccessionedSequence:2132209] factor B [extracellular region] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2173543] Structural analysis of chicken factor B-like protease and comparison with mammalian complement proteins factor B and C2 [LiteratureReference:2173411] Complement C4bC2 complex formation: an investigation by surface plasmon resonance [LiteratureReference:2173527] Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway
modified	[InstanceEdit:2161220] Shamovsky, V, 2012-03-13 [InstanceEdit:2314556] Shamovsky, V, 2012-06-07 [InstanceEdit:2859048] Shamovsky, V, 2012-12-19 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465608] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:6792903] Shamovsky, Veronica, 2015-08-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9628181] Shamovsky, Veronica, 2018-11-06 [InstanceEdit:9645324] Shamovsky, Veronica, 2019-05-08 [InstanceEdit:9645341] Shamovsky, Veronica, 2019-05-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of C4b:factor B complex
output	[Complex:2132183] C4b:factor B [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:2132248] C4b binds to target cell surface [Gallus gallus] [BlackBoxEvent:2132233] Proteolytic cleavage of complement factor C4 [Gallus gallus]
regulatedBy	[PositiveRegulation:2132105] Positive regulation by 'Mg2+ [extracellular region]'
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5644252] R-GGA-2132096.6
summation	[Summation:2173515] Mammalian C2 binds to surface-bound C4b to form the C4b:C2 c...
(hasEvent)	[Pathway:2132263] Creation of classical C3 convertase [Gallus gallus]
(precedingEvent)	[Reaction:2132222] Cleavage of factor B to form classical C3 convertase [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9777693] Update Tracker - [Reaction:2132096] Formation of C4b:factor B complex - v69:[addLiteratureReference, add_removeInput, modifyText] [_UpdateTracker:9778807] Update Tracker - [Reaction:2132096] Formation of C4b:factor B complex - v67:[add_removeInput]
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