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Details on Person Cleavage of C3 by surface-bound C3 convertases

Class:Id	Reaction:2132085
_displayName	Cleavage of C3 by surface-bound C3 convertases
_doRelease	TRUE
_timestamp	2014-11-20 02:39:08
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
catalystActivity	[CatalystActivity:2132138] serine-type endopeptidase activity of C3 convertases [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
input	[Complex:2132153] complement factor C3 [extracellular region] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2132164] Purification of chicken C3 and a structural and functional characterization [LiteratureReference:2132067] Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family [Book:3009251] Innate Immunity 978-081-534123-9 Immunobiology Janeway C, Jr
modified	[InstanceEdit:2173592] Shamovsky, V, 2012-03-30 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465607] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of C3 by surface-bound C3 convertases
output	[EntityWithAccessionedSequence:2132116] C3a [extracellular region] [Gallus gallus] [Complex:2132189] C3b [extracellular region] [Gallus gallus]
precedingEvent	[Reaction:2132222] Cleavage of factor B to form classical C3 convertase [Gallus gallus] [Reaction:2132065] C1r activates C1s component within C1 complement complex [Gallus gallus] [Reaction:2132206] MASPs activation [Gallus gallus] [Reaction:2132096] Formation of C4b:factor B complex [Gallus gallus] [Reaction:2132100] Fluid-phase proteolytic cleavage of factor B [Gallus gallus] [Reaction:2132104] Complement factor B binds to the hydrolyzed form of C3 [Gallus gallus] [Reaction:2132074] Cleavage of surface-bound factor B [Gallus gallus] [Reaction:2132061] Complement factor B binds to surface-bound C3b fragment [Gallus gallus]
regulatedBy	[NegativeRegulation:2132055] Negative regulation by 'CREG:C3 convertases [plasma membrane]' [NegativeRegulation:2132155] Negative regulation by 'CREM:C3b/C4b [plasma membrane]'
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5644488] R-GGA-2132085.3
summation	[Summation:2173311] In mammals, three pathways of complement activation - altern...
(hasEvent)	[Pathway:2132285] Complement Cascade [Gallus gallus]
(precedingEvent)	[BlackBoxEvent:2132201] Opsonization with C3b or C4b [Gallus gallus] [Reaction:2132210] C3b fragment binds to the target cell surface [Gallus gallus] [Reaction:2132264] Formation of alternate C5 convertase [Gallus gallus] [Reaction:2132269] Formation of classical C5 convertase [Gallus gallus] [Reaction:2132277] Complement factor H binds to surface-bound C3b [Gallus gallus] [Reaction:2173317] C3a anaphylatoxin binds C3a receptor [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9786015] Update Tracker - [Reaction:2132085] Cleavage of C3 by surface-bound C3 convertases - v50:[add_removeRegulator]
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No pathways have been reviewed or authored by Cleavage of C3 by surface-bound C3 convertases (2132085)