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Details on Person Cleavage of surface-bound factor B

Class:Id	Reaction:2132074
_displayName	Cleavage of surface-bound factor B
_doRelease	TRUE
_timestamp	2014-11-20 02:31:28
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
catalystActivity	[CatalystActivity:2859046] serine-type endopeptidase activity of complement factor D [extracellular region]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
inferredFrom	[Reaction:183122] Factor D cleaves C3b-bound Factor B [Homo sapiens]
input	[Complex:2132144] C3b:factor B [plasma membrane] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2314456] Activation of chicken alternative complement pathway by fowlpox virus-infected cells [LiteratureReference:2314512] The alternative complement pathway in chickens. Purification of factor B and production of a monospecific antibody against it [LiteratureReference:2132067] Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family [LiteratureReference:2314503] Lysis of horse red blood cells mediated by antibody-independent activation of the alternative pathway of chicken complement [LiteratureReference:2132164] Purification of chicken C3 and a structural and functional characterization [LiteratureReference:2173543] Structural analysis of chicken factor B-like protease and comparison with mammalian complement proteins factor B and C2
modified	[InstanceEdit:2314547] Shamovsky, V, 2012-06-07 [InstanceEdit:2530595] Shamovsky, V, 2012-10-17 [InstanceEdit:2859047] Shamovsky, V, 2012-12-19 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465607] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of surface-bound factor B
output	[EntityWithAccessionedSequence:2132068] factor Ba [extracellular region] [Gallus gallus] [Complex:2132200] C3b:Bb [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:2132061] Complement factor B binds to surface-bound C3b fragment [Gallus gallus] [Reaction:2132210] C3b fragment binds to the target cell surface [Gallus gallus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5644239] R-GGA-2132074.2
summation	[Summation:2314494] Human factor B is cleaved by factor D yielding a small fragm...
(hasEvent)	[Pathway:2132273] Formation of membrane-bound convertase C3 [Gallus gallus]
(precedingEvent)	[Reaction:2132085] Cleavage of C3 by surface-bound C3 convertases [Gallus gallus] [Reaction:2132254] CD55(DAF) binds to surface-bound C3 convertases [Gallus gallus] [Reaction:2132264] Formation of alternate C5 convertase [Gallus gallus] [Reaction:2173323] Cleavage of C3 by fluid-phase C3i:factor B [Gallus gallus] [Reaction:2530573] CREG(CR1L) binds to surface-bound C3 convertases [Gallus gallus] [Reaction:2530584] CREM (CREMP) binds to surface-bound C3b or C4b [Gallus gallus]
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