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Details on Person Complement factor B binds to surface-bound C3b fragment

Class:Id	Reaction:2132061
_displayName	Complement factor B binds to surface-bound C3b fragment
_doRelease	TRUE
_timestamp	2014-11-20 02:35:32
authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
inferredFrom	[Reaction:183126] Factor B binds to surface-associated C3b [Homo sapiens]
input	[Complex:2132202] C3b [plasma membrane] [Gallus gallus] [EntityWithAccessionedSequence:2132209] factor B [extracellular region] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2132164] Purification of chicken C3 and a structural and functional characterization [LiteratureReference:2132067] Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family [LiteratureReference:182527] Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins
modified	[InstanceEdit:2173595] Shamovsky, V, 2012-03-30 [InstanceEdit:2314677] Shamovsky, V, 2012-06-07 [InstanceEdit:3009248] Shamovsky, V, 2013-02-05 [InstanceEdit:3465608] Shamovsky, V, 2013-05-17 [InstanceEdit:3632869] Shamovsky, V, 2013-05-28 [InstanceEdit:3632870] Shamovsky, V, 2013-05-28 [InstanceEdit:5083130] Shamovsky, V, 2013-11-05 [InstanceEdit:5149551] Matthews, L, 2013-11-20 [InstanceEdit:5324712] Shamovsky, V, 2014-02-18 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Complement factor B binds to surface-bound C3b fragment
output	[Complex:2132144] C3b:factor B [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:2132210] C3b fragment binds to the target cell surface [Gallus gallus] [Reaction:2132085] Cleavage of C3 by surface-bound C3 convertases [Gallus gallus] [Reaction:2173323] Cleavage of C3 by fluid-phase C3i:factor B [Gallus gallus]
regulatedBy	[PositiveRegulation:2161222] Positive regulation by 'Mg2+ [extracellular region]'
releaseDate	2014-03-12
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:5644376] R-GGA-2132061.3
summation	[Summation:2314675] Surface-bound C3b interacts with factor B which in turn is c...
(hasEvent)	[Pathway:2132273] Formation of membrane-bound convertase C3 [Gallus gallus]
(precedingEvent)	[Reaction:2132074] Cleavage of surface-bound factor B [Gallus gallus] [Reaction:2132271] Factor H displaces Bb in Cb:Bb complex [Gallus gallus]
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