Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person MHC class II antigen processing

Class:Id	Reaction:2130706
_displayName	MHC class II antigen processing
_doRelease	TRUE
_timestamp	2026-04-27 18:36:51
authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
catalystActivity	[CatalystActivity:2130638] cysteine-type endopeptidase activity of Cathepsin [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
input	[OtherEntity:2213225] unfolded antigen [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:2213080] Asparaginyl endopeptidase: case history of a class II MHC compartment protease [LiteratureReference:2213129] Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies [LiteratureReference:2213070] Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation [LiteratureReference:2213112] Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice [LiteratureReference:2213157] Specific role for cathepsin S in the generation of antigenic peptides in vivo
modified	[InstanceEdit:2213242] Garapati, P V, 2012-04-30 [InstanceEdit:2247929] Garapati, P V, 2012-05-14 [InstanceEdit:2250299] Garapati, P V, 2012-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	MHC class II antigen processing
output	[OtherEntity:2213226] MHC class II epitopes [lysosomal lumen] [OtherEntity:2213226] MHC class II epitopes [lysosomal lumen] [OtherEntity:2213226] MHC class II epitopes [lysosomal lumen]
precedingEvent	[Reaction:2213240] Reduction of disulphide bonds in MHC II antigens [Homo sapiens] [BlackBoxEvent:2130627] MHC class II antigen internalization [Homo sapiens] [BlackBoxEvent:9941556] Endocytosis of BCR:Antigen [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294667] R-HSA-2130706.3
summation	[Summation:2130494] Antigen processing and loading on to MHC class II molecules ...
(hasEvent)	[Pathway:2132295] MHC class II antigen presentation [Homo sapiens] [Pathway:2132296] Class II antigen processing [Homo sapiens] [Pathway:9979719] Processing of antigen in germinal center B cells [Homo sapiens]
(precedingEvent)	[Reaction:2213244] Loading of antigenic peptides [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984731] Update Tracker - [Reaction:2130706] MHC class II antigen processing - v96:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by MHC class II antigen processing (2130706)