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Details on Person Translocation of TGN-lysosome vesicle to lysosome

Class:Id	Reaction:2130641
_displayName	Translocation of TGN-lysosome vesicle to lysosome
_doRelease	TRUE
_timestamp	2012-05-31 09:38:16
authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
catalystActivity	[CatalystActivity:2213237] GTPase activity of Dynamin [cytosol]
compartment	[Compartment:263163] trans-Golgi network membrane [Compartment:70101] cytosol
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
input	[Complex:2130552] AP-1 Clathrin coated nonameric complex [trans-Golgi network membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2130462] A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway [LiteratureReference:2130464] MHC class II-associated invariant chain contains a sorting signal for endosomal compartments [LiteratureReference:2130454] Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain [LiteratureReference:2130374] Expression of major histocompatibility complex class II molecules in HeLa cells promotes the recruitment of AP-1 Golgi-specific assembly proteins on Golgi membranes [LiteratureReference:2130726] Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera [LiteratureReference:2130580] Medium chains of adaptor complexes AP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain [LiteratureReference:2130498] The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains
modified	[InstanceEdit:2213242] Garapati, P V, 2012-04-30 [InstanceEdit:2247929] Garapati, P V, 2012-05-14 [InstanceEdit:2250299] Garapati, P V, 2012-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translocation of TGN-lysosome vesicle to lysosome
output	[CandidateSet:2213185] Dynamin [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol] [SimpleEntity:29372] Pi [cytosol] [Complex:2213234] TGN-lysosome vesicle with nonameric complex [trans-Golgi network membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2130619] TGN-lysosomal vesicle coat assembly [Homo sapiens] [BlackBoxEvent:2130393] Transport of MHC II:Ii complex along Golgi to TGN [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294674] R-HSA-2130641.2
summation	[Summation:2213089] Budding vesicles loaded with the nonameric complex bud off f...
(hasEvent)	[Pathway:2132295] MHC class II antigen presentation [Homo sapiens]
(precedingEvent)	[Reaction:2213236] TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome [Homo sapiens]
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No pathways have been reviewed or authored by Translocation of TGN-lysosome vesicle to lysosome (2130641)