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Details on Person Interaction of invariant chain trimer and MHC II alpha beta dimer

Class:Id	Reaction:2130478
_displayName	Interaction of invariant chain trimer and MHC II alpha beta dimer
_doRelease	TRUE
_timestamp	2024-05-16 16:17:43
authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
compartment	[Compartment:5263265] lumenal side of endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
input	[Complex:2130599] Invariant chain trimer [lumenal side of endoplasmic reticulum membrane] [Homo sapiens] [Complex:2213186] MHC II alpha beta heterodimer [lumenal side of endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:195906] CANX [endoplasmic reticulum lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2130436] Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain [LiteratureReference:2130307] Invariant chain transmembrane domain trimerization: a step in MHC class II assembly [LiteratureReference:2130535] Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region [LiteratureReference:2130510] Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding [LiteratureReference:2130526] Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum [LiteratureReference:2130319] A role for calnexin (IP90) in the assembly of class II MHC molecules [LiteratureReference:2230997] Invariant chain increases the half-life of MHC II by delaying endosomal maturation
modified	[InstanceEdit:2213242] Garapati, P V, 2012-04-30 [InstanceEdit:2220950] Jupe, S, 2012-05-03 [InstanceEdit:2230999] Garapati, P V, 2012-05-07 [InstanceEdit:2247929] Garapati, P V, 2012-05-14 [InstanceEdit:2250299] Garapati, P V, 2012-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9910705] D'Eustachio, Peter, 2024-05-16
name	Interaction of invariant chain trimer and MHC II alpha beta dimer
output	[Complex:2213212] alpha beta dimer:Ii trimer:calnexin [lumenal side of endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:2213239] Formation of MHC II alpha beta heterodimer [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295234] R-HSA-2130478.3
summation	[Summation:2130631] MHC II alpha beta dimers associate with a third polypeptide,...
(hasEvent)	[Pathway:2132295] MHC class II antigen presentation [Homo sapiens]
(precedingEvent)	[Reaction:2213241] Formation of nonameric complex [Homo sapiens]
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No pathways have been reviewed or authored by Interaction of invariant chain trimer and MHC II alpha beta dimer (2130478)