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Details on Person Second mitochondria derived activator of caspase/direct inhi...
| Class:Id | Summation:212971 |
|---|---|
| _displayName | Second mitochondria derived activator of caspase/direct inhi... |
| _timestamp | 2018-11-02 01:43:20 |
| created | [InstanceEdit:212958] Matthews, L, 2008-02-15 23:39:43 |
| literatureReference | [LiteratureReference:9627083] A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis [LiteratureReference:6804352] A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases [LiteratureReference:140369] IAP proteins: blocking the road to death's door [LiteratureReference:9627061] Structural and biochemical basis of apoptotic activation by Smac/DIABLO [LiteratureReference:9627437] Structural basis of IAP recognition by Smac/DIABLO [LiteratureReference:9627380] Structural basis of caspase-7 inhibition by XIAP [LiteratureReference:9627409] Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac |
| modified | [InstanceEdit:1458595] D'Eustachio, P, 2011-07-21 [InstanceEdit:5577005] Matthews, Lisa, 2014-05-28 [InstanceEdit:9627414] Shamovsky, Veronica, 2018-11-02 |
| text | Second mitochondria derived activator of caspase/direct inhibitor of apoptosis binding protein with low pI (SMAC, also known as DIABLO) regulates XIAP function and potentiates caspase-3, -7 and -9 activity by disrupting the interaction of caspases with XIAP. Residues 56-59 of SMAC (DIABLO) are homologous to the amino-terminal motif that is used by caspase-9 (CASP9) to bind to the BIR3 domain of XIAP. SMAC (DIABLO) competes with CASP9 for binding to BIR3 domain of XIAP promoting the release of XIAP from the CASP9:apoptosome complex (Srinivasula SM et al. 2001; Salvesen et al. 2002). The binding of SMAC to the BIR2 and BIR3 regions of XIAP creates a steric hindrance that is essential for preventing binding of XIAP linker region with effector caspases CASP3 and CASP7 thus achieving neutralization of XIAP inhibition. The strong affinity for XIAP allows SMAC (DIABLO) to displace caspase-3, -7 from the XIAP:caspase complexes (Wu G et al. 2000; Chai J et al. 2001; Huang Y et al. 2003; Abhari BA & Davoodi J 2008). |
| (summation) | [Pathway:111464] SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes [Homo sapiens] |
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No pathways have been reviewed or authored by Second mitochondria derived activator of caspase/direct inhi... (212971)
