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Details on Person Second mitochondria‑derived activator of caspases protein (S...

Class:IdSummation:212960
_displayNameSecond mitochondria‑derived activator of caspases protein (S...
_timestamp2018-11-02 01:43:22
created[InstanceEdit:212958] Matthews, L, 2008-02-15 23:39:43
literatureReference[LiteratureReference:9627061] Structural and biochemical basis of apoptotic activation by Smac/DIABLO
[LiteratureReference:9627437] Structural basis of IAP recognition by Smac/DIABLO
[LiteratureReference:114477] X-linked IAP is a direct inhibitor of cell-death proteases.
[LiteratureReference:9627344] Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
[LiteratureReference:6804352] A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases
[LiteratureReference:9627433] Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation
[LiteratureReference:9627415] Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes
[LiteratureReference:3148617] Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
modified[InstanceEdit:1458594] D'Eustachio, P, 2011-07-21
[InstanceEdit:9627111] Shamovsky, Veronica, 2018-11-01
[InstanceEdit:9627414] Shamovsky, Veronica, 2018-11-02
textSecond mitochondria‑derived activator of caspases protein (SMAC, also known as direct IAP binding protein with low pI or DIABLO) in its dimeric form interacts and antagonizes X‑linked inhibitor of apoptosis protein (XIAP) by concurrently targeting both BIR2 and BIR3 domains of XIAP (Chai J et al. 2000; Liu Z et sl. 2000; Burke SP & Smith JB 2010). XIAP inhibits apoptosis by binding to and inhibiting the effectors caspase‑3 and ‑7 and an initiator caspase‑9 (Deveraux QL et al. 1997; Paulsen M et al. 2008). During apoptosis, SMAC (DIABLO) is released from the mitochondria (Du C et al. 2000). In the cytosol, SMAC binds to XIAP displacing it from caspase:XIAP complexes liberating the active caspases (Wu G et al. 2000; Abhari BA & Davoodi J 2008).
(summation)[Pathway:111463] SMAC (DIABLO) binds to IAPs [Homo sapiens]
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