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Details on Person Microfibrils are composed largely of fibrillin but also cont...

Class:IdSummation:2129369
_displayNameMicrofibrils are composed largely of fibrillin but also cont...
_timestamp2012-11-01 13:16:48
created[InstanceEdit:2129374] Jupe, S, 2012-02-21
literatureReference[LiteratureReference:2426499] The protein components of the 12-nanometer microfibrils of elastic and nonelastic tissues
[LiteratureReference:2426532] The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin
[LiteratureReference:2426520] Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1
[LiteratureReference:2537644] Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems
[LiteratureReference:2426452] Microfibril-associated glycoprotein-2 (MAGP-2) is specifically associated with fibrillin-containing microfibrils but exhibits more restricted patterns of tissue localization and developmental expression than its structural relative MAGP-1
modified[InstanceEdit:2328049] Jupe, S, 2012-06-22
[InstanceEdit:2328179] Jupe, S, 2012-06-25
[InstanceEdit:2396250] Jupe, S, 2012-07-09
[InstanceEdit:2426542] Jupe, S, 2012-08-03
[InstanceEdit:2537643] Jupe, S, 2012-10-31
[InstanceEdit:2545194] Jupe, S, 2012-11-01
textMicrofibrils are composed largely of fibrillin but also contain covalently-linked microfibril associated glycoproteins MAGP-1 (MFAP2) and MAGP-2 (MFAP5). MFAP2 is a structural component of almost all vertebrate microfibrils (Gibson et al. 1989, Trask et al. 2000, Jensen et al. 2001). It appears to be important for tissue development and/or homeostasis, including regulation of bone remodelling and deposition of tissue fat (Weinbaum et al. 2008). The C-terminal half of MFAP2 is rich in cysteines and contains a matrix-binding domain that facilitates interactions with fibrillin (Weinbaum et al. 2008). The related MFAP5 similarly binds to microfibrils (Gibson et al. 1998) but with a restricted expression profile.
(summation)[Reaction:2129385] MFAP2, MFAP5 bind microfibrils [Homo sapiens]
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