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Details on Person STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7

Class:Id	Reaction:2128994
_displayName	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
_doRelease	TRUE
_timestamp	2012-05-31 09:52:36
authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:2128995] Orlic-Milacic, M, 2012-02-17
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10
input	[Complex:2127564] TGFB1:p-TGFBR:STRAP [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:173478] SMAD7 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2128996] STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling
modified	[InstanceEdit:2130225] Orlic-Milacic, M, 2012-02-21 [InstanceEdit:2187532] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2197658] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2250363] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
output	[Complex:2128993] TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2127562] STRAP binds phosphorylated TGF-beta receptor complex [Homo sapiens] [Reaction:170843] TGFBR2 phosphorylates TGFBR1 [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295238] R-HSA-2128994.2
summation	[Summation:2130223] STRAP binds both TGF-beta receptor and SMAD7, and stabilizes...
(hasEvent)	[Pathway:2173788] Downregulation of TGF-beta receptor signaling [Homo sapiens]
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No pathways have been reviewed or authored by STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (2128994)