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Details on Person SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2

Class:Id	Reaction:2127257
_displayName	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2
_doRelease	TRUE
_timestamp	2022-05-09 21:48:56
authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2127256] Orlic-Milacic, M, 2012-02-14
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
input	[Complex:2127252] RBL1:E2F4/5:DP1/2 [nucleoplasm] [Homo sapiens] [DefinedSet:173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1484105] E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
modified	[InstanceEdit:2187535] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2197659] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2250342] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:9754438] Orlic-Milacic, Marija, 2021-09-24 [InstanceEdit:9773749] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2
negativePrecedingEvent	[NegativePrecedingEvent:9754419] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
output	[Complex:2127250] p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens] [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294997] R-HSA-2127257.4
summation	[Summation:2127258] In response to TGF-beta stimulation, a complex composed of S...
(hasEvent)	[Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(precedingEvent)	[Reaction:9736984] p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter [Homo sapiens]
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No pathways have been reviewed or authored by SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (2127257)