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Details on Person EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]

Class:Id	Complex:212717
_displayName	EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
_timestamp	2018-10-11 15:14:08
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:212707] Jassal, Bijay, 2008-02-13
hasComponent	[EntityWithAccessionedSequence:202320] PLCG1 [cytosol] [Homo sapiens] [Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:179803] p-6Y-EGFR [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:179803] p-6Y-EGFR [plasma membrane] [Homo sapiens] [DefinedSet:9624194] EGF-like ligands [extracellular region] [Homo sapiens] [DefinedSet:9624194] EGF-like ligands [extracellular region] [Homo sapiens]
modified	[InstanceEdit:1483239] Orlic-Milacic, Marija, 2011-08-12 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:2231000] Matthews, L, 2012-05-07 [InstanceEdit:9624452] Rothfels, Karen, 2018-10-11
name	EGF-like ligands:p-6Y-EGFR:PLCG1 Activated EGFR:PLC-gamma1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:364247] R-HSA-212717.2
(input)	[Reaction:212710] EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens] [Reaction:9846406] GOCAM EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:5637726] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] [EntityFunctionalStatus:9630162] gain_of_function of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
(output)	[Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor [Homo sapiens] [Reaction:9846379] GOCAM Phospholipase C-gamma1 binds to the activated EGF receptor [Homo sapiens]
(physicalEntity)	[CatalystActivity:212705] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] [CatalystActivity:9851169] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
(updatedInstance)	[_UpdateTracker:9870610] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v38:[addName, updateContainedComponent] [_UpdateTracker:9871205] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v39:[updateContainedComponent] [_UpdateTracker:9871497] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v40:[addCompartment] [_UpdateTracker:9872435] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [_UpdateTracker:9894665] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v57:[updateContainedComponent] [_UpdateTracker:9899926] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v67:[add_removeHasComponent, modifyName]
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No pathways have been reviewed or authored by EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (212717)