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Details on Person Phospholipase C-gamma1 binds to the activated EGF receptor

Class:Id	Reaction:212706
_displayName	Phospholipase C-gamma1 binds to the activated EGF receptor
_doRelease	TRUE
_timestamp	2024-03-19 12:24:54
authored	[InstanceEdit:212714] Jassal, Bijay, 2008-02-13
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:212707] Jassal, Bijay, 2008-02-13
input	[EntityWithAccessionedSequence:202320] PLCG1 [cytosol] [Homo sapiens] [Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro [LiteratureReference:212712] Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor
modified	[InstanceEdit:213066] Jassal, Bijay, 2008-02-20 [InstanceEdit:213070] Jassal, Bijay, 2008-02-20 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:981696] Jassal, Bijay, 2010-10-26 [InstanceEdit:2018637] Jassal, Bijay, 2011-11-23 [InstanceEdit:9624472] Rothfels, Karen, 2018-10-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
name	Phospholipase C-gamma1 binds to the activated EGF receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865810] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
output	[Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:177937] Phosphorylation of EGFR by SRC kinase [Homo sapiens] [Reaction:177922] EGFR dimerization [Homo sapiens] [Reaction:177934] EGFR autophosphorylation [Homo sapiens] [Reaction:177922] EGFR dimerization [Homo sapiens] [Reaction:9851407] FAM83B, (FAM83A, FAM83D) bind EGFR [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361826] R-HSA-212706.4
summation	[Summation:213065] Inactive phospholipase C-gamma1 (PLCG1) binds to activated e...
(hasEvent)	[Pathway:212718] EGFR interacts with phospholipase C-gamma [Homo sapiens]
(normalReaction)	[Reaction:1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants [Homo sapiens] [Reaction:5637792] PLC-gamma 1 binds to p-EGFRvIII mutant [Homo sapiens]
(precedingEvent)	[Reaction:212710] EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778885] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v67:[add_removeInput] [_UpdateTracker:9788877] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v40:[add_removeInput] [_UpdateTracker:9789081] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v38:[modifyText]
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