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Details on Person Specific Coactivator Complexes for DNA-binding Transcription...
| Class:Id | Summation:212335 |
|---|---|
| _displayName | Specific Coactivator Complexes for DNA-binding Transcription... |
| _timestamp | 2008-02-15 14:38:36 |
| created | [InstanceEdit:212387] Caudy, M, 2008-02-08 22:45:45 |
| modified | [InstanceEdit:212857] Caudy, M, 2008-02-14 20:40:37 [InstanceEdit:212925] Caudy, M, 2008-02-15 14:38:29 |
| text | Specific Coactivator Complexes for DNA-binding Transcription Factors. A number of specific co-activator complexes for DNA-binding transcription factors have been identified, including DRIP, TRAP, and ARC (reviewed in Bourbon, 2004, Blazek, 2005, Conaway, 2005, and Malik, 2005). The DRIP co-activator complex was originally identified and named as a specific complex associated with the Vitamin D Receptor member of the nuclear receptor family of transcription factors (Rachez, 1998). Similarly, the TRAP co-activator complex was originally identified as a complex that associates with the thyroid receptor (Yuan, 1998). It was later determined that all of the components of the DRIP complex are also present in the TRAP complex, and the ARC complex (discussed further below). For example, the DRIP205 and TRAP220 proteins were show to be identical, as were specific pairs of the other components of these complexes (Rachez, 1999). In addition, these various transcription co-activator proteins identified in mammalian cells were found to be the orthologues or homologues of the Mediator ("adaptor") complex proteins (reviewed in Bourbon, 2004). The Mediator proteins were originally identified in yeast by Kornberg and colleagues, as complexes associated with DNA polymerase (Kelleher, 1990). In higher organisms, Adapter complexes bridge between the basal transcription factors (including Pol II) and tissue-specific transcription factors (TFs) bound to sites within upstream Proximal Promoter regions or distal Enhancer regions (Figure 1). However, many of the Mediator homologues can also be found in complexes associated with specific transcription factors in higher organisms. A unified nomenclature system for these adapter / co-activator proteins now labels them Mediator 1 through Mediator 31 (Bourbon, 2004). For example, the DRIP205 / TRAP220 proteins are now identified as Mediator 1 (Rachez, 1999), based on homology with yeast Mediator 1. References: Mediator / Adapter / Co-Activator Complexes Blazek, E., Mittler, G., and Meisterernst, M. (2005). The mediator of RNA polymerase II. Chromosoma 113, 399-408. Bourbon, H. M., Aguilera, A., Ansari, A. Z., Asturias, F. J., Berk, A. J., Bjorklund, S., Blackwell, T. K., Borggrefe, T., Carey, M., Carlson, M., et al. (2004). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14, 553-557. Conaway, J. W., Florens, L., Sato, S., Tomomori-Sato, C., Parmely, T. J., Yao, T., Swanson, S. K., Banks, C. A., Washburn, M. P., and Conaway, R. C. (2005). The mammalian Mediator complex. FEBS Lett 579, 904-908. Malik, S., and Roeder, R. G. (2005). Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci 30, 256-263. Rachez, C., Lemon, B. D., Suldan, Z., Bromleigh, V., Gamble, M., Naar, A. M., Erdjument-Bromage, H., Tempst, P., and Freedman, L. P. (1999). |
| (summation) | [Reaction:212329] Formation of CSL Hairless corepressor complex [Homo sapiens] |
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