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Details on Person PRC2 (EZH2) Core [nucleoplasm]

Class:IdComplex:212285
_displayNamePRC2 (EZH2) Core [nucleoplasm]
_timestamp2013-12-24 22:33:38
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:212319] May, B, Gopinathrao, G, 2008-02-08 20:37:25
hasComponent
literatureReference[LiteratureReference:212296] Role of histone H3 lysine 27 methylation in Polycomb-group silencing
[LiteratureReference:212244] Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
[LiteratureReference:5082347] SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
[LiteratureReference:5082343] Molecular architecture of human polycomb repressive complex 2
[LiteratureReference:1022081] Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3
modified[InstanceEdit:417269] May, B, 2009-04-12 09:31:33
[InstanceEdit:565730] May, B, 2010-04-06
[InstanceEdit:1022082] May, B, 2010-11-17
[InstanceEdit:3239851] Orlic-Milacic, M, 2013-03-27
[InstanceEdit:3240280] Orlic-Milacic, M, 2013-03-27
[InstanceEdit:4839774] May, B, 2013-11-03
[InstanceEdit:5082349] May, B, 2013-11-04
[InstanceEdit:5084062] May, B, 2013-11-08
[InstanceEdit:5220523] May, B, 2013-12-24
namePRC2 (EZH2) Core
Polycomb Repressive Complex 2 (PRC2) Core
SUZ12:EED:EZH2:RpAp46,48
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545445] R-HSA-212285.1
summation[Summation:212250] The human Polycomb Repressive Complex 2 (PRC2) is homologous...
(activeUnit)[CatalystActivity:9815908] histone H3K27 methyltransferase activity of PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm]
[NegativeGeneExpressionRegulation:9815906] Negative gene expression regulation by 'PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9909650] Negative gene expression regulation by 'PRC2(EZH2) Core:H3K27me3 Nucleosome:CD274 gene [nucleoplasm]'
(hasCandidate)[CandidateSet:8943822] PRC1.4,PRC2 (EZH2) core [nucleoplasm] [Homo sapiens]
(hasComponent)[Complex:3211702] PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] [Homo sapiens]
[Complex:5084065] PRC2 (EZH2) Core:AEBP2 [nucleoplasm] [Homo sapiens]
[Complex:5084071] PRC2 Core:Chromatin [nucleoplasm] [Homo sapiens]
[Complex:5084072] PRC2:JARID2:MTF2 [nucleoplasm] [Homo sapiens]
[Complex:5084076] PRC2:PHF19 [nucleoplasm] [Homo sapiens]
[Complex:5084089] PRC2:PHF1 [nucleoplasm] [Homo sapiens]
[Complex:5617465] RARA,G:RXRA at HOXA1 bivalent chromatin [nucleoplasm] [Homo sapiens]
[Complex:5617473] HOXD1 bivalent chromatin [nucleoplasm] [Homo sapiens]
[Complex:5617474] RARA,G:RXRA at HOXB1 bivalent chromatin [nucleoplasm] [Homo sapiens]
[Complex:5617482] HOXB2 bivalent chromatin [nucleoplasm] [Homo sapiens]
List all 37 refering instances
(hasMember)[DefinedSet:5084084] PRC2 [nucleoplasm] [Homo sapiens]
[DefinedSet:9965980] PRC2 (EZH1,EZH2) core [nucleoplasm] [Homo sapiens]
(input)[Reaction:8954110] E2F6:TFDP1:EPC1 binds the PRC2 complex [Homo sapiens]
[Reaction:9614816] Latent Transcriptinally Repressed HCMV Genome [Homo sapiens]
[Reaction:9764930] PRC2 (EZH2) core complex binds CDH1 gene promoter [Homo sapiens]
[Reaction:9909611] PRC2(EZH2) core binding to CD274 gene promoter [Homo sapiens]
[Reaction:9983755] LANA1 recruits the PRC2 complex [Homo sapiens]
(output)[Reaction:3240957] Formation of PRC2-EZH2 complex [Homo sapiens]
[BlackBoxEvent:5617431] Retinoic acid activates HOXA1 chromatin [Homo sapiens]
[BlackBoxEvent:5617445] HOXD1 chromatin is activated [Homo sapiens]
[BlackBoxEvent:5617452] Retinoic acid activates HOXB1 chromatin [Homo sapiens]
[BlackBoxEvent:5617650] HOXD3 chromatin is activated [Homo sapiens]
[BlackBoxEvent:5617859] Retinoic acid activates HOXB4 chromatin [Homo sapiens]
[BlackBoxEvent:5617862] Retinoic acid activates HOXA4 chromatin [Homo sapiens]
[BlackBoxEvent:5617887] HOXC4 chromatin is activated [Homo sapiens]
[BlackBoxEvent:5617896] Retinoic acid activates HOXD4 chromatin [Homo sapiens]
[BlackBoxEvent:5624433] HOXA5 chromatin is activated [Homo sapiens]
List all 25 refering instances
(physicalEntity)[CatalystActivity:3240298] histone H3K27 methyltransferase activity of PRC2 (EZH2) Core [nucleoplasm]
(updatedInstance)[_UpdateTracker:9888734] Update Tracker - [Complex:212285] PRC2 (EZH2) Core [nucleoplasm] - v47:[addLiteratureReference, add_removeHasComponent, modifyName]
[_UpdateTracker:9889361] Update Tracker - [Complex:212285] PRC2 (EZH2) Core [nucleoplasm] - v48:[addLiteratureReference]
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No pathways have been reviewed or authored by PRC2 (EZH2) Core [nucleoplasm] (212285)
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