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Details on Person EZH2, a SET domain protein, trimethylates histone H3 at lysi...
| Class:Id | Summation:212274 |
|---|---|
| _displayName | EZH2, a SET domain protein, trimethylates histone H3 at lysi... |
| _timestamp | 2025-09-09 17:37:10 |
| created | [InstanceEdit:212319] May, B, Gopinathrao, G, 2008-02-08 20:37:25 |
| literatureReference | [LiteratureReference:212244] Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein [LiteratureReference:212257] Expression patterns and post-translational modifications associated with mammalian histone H3 variants |
| modified | [InstanceEdit:417266] May, B, 2009-04-12 09:30:04 [InstanceEdit:1022082] May, B, 2010-11-17 [InstanceEdit:5219046] May, B, 2013-12-20 [InstanceEdit:5219076] May, B, 2013-12-22 [InstanceEdit:5227039] May, B, 2014-01-09 [InstanceEdit:9966046] Orlic-Milacic, Marija, 2025-09-09 |
| text | EZH2, a SET domain protein, trimethylates histone H3 at lysine 27 (H3K27) and lysine 9 (H3K9) (Kuzmichev et al. 2002, Cao et al. 2002, Kuzmichev et al. 2004, Martin et al. 2006, McCabe et al. 2012, Swalm et al. 2013). EZH2 has greater activity with lysine residues that have fewer methyl groups (unmethylated:monomethylated:dimethylated=9:6:1, McCabe et al. 2012). EZH1 rather than EZH2 is present in some PRC2 complexes and can also catalyze the trimethylation of H3K27 (inferred from mouse in Shen et al. 2008), however EZH1 is also able to repress transcription without methylating histone H3 (Margueron et al. 2008). The catalytic activity of both EZH1- and EZH2-containing PRC2 complexes is inhibited by EZHIP (also known as CXorf67) (Jain et al. 2019, Hubner et al. 2019). |
| (summation) | [Reaction:212263] PRC2 trimethylates histone H3 at lysine-27 [Homo sapiens] |
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