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Details on Person PRC2 trimethylates histone H3 at lysine-27

Class:IdReaction:212263
_displayNamePRC2 trimethylates histone H3 at lysine-27
_doReleaseTRUE
_timestamp2025-09-15 17:48:21
authored[InstanceEdit:212086] May, B, Gopinathrao, G, 2008-02-08 19:50:06
catalystActivity[CatalystActivity:3211728] protein-lysine N-methyltransferase activity of PRC2:Chromatin [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:212319] May, B, Gopinathrao, G, 2008-02-08 20:37:25
edited[InstanceEdit:565730] May, B, 2010-04-06
input[Complex:3211709] PRC2:Chromatin [nucleoplasm] [Homo sapiens]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
internalReviewed[InstanceEdit:9966307] May, Bruce, 2025-09-11
literatureReference[LiteratureReference:212244] Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
[LiteratureReference:212296] Role of histone H3 lysine 27 methylation in Polycomb-group silencing
[LiteratureReference:565724] Substrate preferences of the EZH2 histone methyltransferase complex
[LiteratureReference:1022081] Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3
[LiteratureReference:5218998] Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys˛? methylation by human polycomb repressive complex 2 and vSET
[LiteratureReference:5219043] Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
[LiteratureReference:5219071] Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
[LiteratureReference:9965936] PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
[LiteratureReference:9965948] EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma
modified[InstanceEdit:417286] May, B, 2009-04-12 09:50:45
[InstanceEdit:417288] May, B, 2009-04-12 09:54:45
[InstanceEdit:427542] May, B, 2009-06-23
[InstanceEdit:433758] May, B, 2009-08-25
[InstanceEdit:565730] May, B, 2010-04-06
[InstanceEdit:573322] May, B, 2010-04-10
[InstanceEdit:1022082] May, B, 2010-11-17
[InstanceEdit:3211737] May, B, 2013-03-08
[InstanceEdit:5084121] May, B, 2013-11-08
[InstanceEdit:5219051] May, B, 2013-12-20
[InstanceEdit:5219076] May, B, 2013-12-22
[InstanceEdit:5227039] May, B, 2014-01-09
[InstanceEdit:5250950] May, B, 2014-01-31
[InstanceEdit:5263608] May, B, 2014-02-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9965848] Orlic-Milacic, Marija, 2025-09-05
[InstanceEdit:9966046] Orlic-Milacic, Marija, 2025-09-09
[InstanceEdit:9966308] Orlic-Milacic, Marija, 2025-09-15
namePRC2 trimethylates histone H3 at lysine-27
output[Complex:3211731] PRC2:Chromatin (H3K27me3) [nucleoplasm] [Homo sapiens]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[NegativeRegulation:9965838] Negative regulation by 'EZHIP:PRC2:Chromatin [nucleoplasm]'
releaseDate2014-03-12
reviewed[InstanceEdit:5263607] Di Croce, Luciano, 2014-02-11
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:9966046] Orlic-Milacic, Marija, 2025-09-09
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644333] R-HSA-212263.3
structureModified[InstanceEdit:9965848] Orlic-Milacic, Marija, 2025-09-05
summation[Summation:212274] EZH2, a SET domain protein, trimethylates histone H3 at lysi...
(hasEvent)[Pathway:212300] PRC2 methylates histones and DNA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9971810] Update Tracker - [Reaction:212263] PRC2 trimethylates histone H3 at lysine-27 - v95:[modifyText, removeLiteratureReference, removeRegulator]
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