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Details on Person Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin

Class:IdBlackBoxEvent:212252
_displayNamePolycomb Repressive Complex 2 (PRC2) Is recruited to chromatin
_doReleaseTRUE
_timestamp2025-09-15 17:48:26
authored[InstanceEdit:212086] May, B, Gopinathrao, G, 2008-02-08 19:50:06
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:212319] May, B, Gopinathrao, G, 2008-02-08 20:37:25
edited[InstanceEdit:565730] May, B, 2010-04-06
input[Complex:3211736] Chromatin [nucleoplasm] [Homo sapiens]
[DefinedSet:5084084] PRC2 [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9966307] May, Bruce, 2025-09-11
literatureReference[LiteratureReference:3211720] Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
[LiteratureReference:3211717] Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
[LiteratureReference:3211693] GC-rich sequence elements recruit PRC2 in mammalian ES cells
[LiteratureReference:3211678] A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
[LiteratureReference:3211729] JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
[LiteratureReference:3211705] Jarid2 and PRC2, partners in regulating gene expression
[LiteratureReference:5211374] Noncoding RNA and Polycomb recruitment
[LiteratureReference:5218975] Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)
modified[InstanceEdit:417267] May, B, 2009-04-12 09:30:48
[InstanceEdit:565730] May, B, 2010-04-06
[InstanceEdit:573322] May, B, 2010-04-10
[InstanceEdit:1022082] May, B, 2010-11-17
[InstanceEdit:3211737] May, B, 2013-03-08
[InstanceEdit:5084121] May, B, 2013-11-08
[InstanceEdit:5211378] May, B, 2013-12-10
[InstanceEdit:5219052] May, B, 2013-12-20
[InstanceEdit:5250950] May, B, 2014-01-31
[InstanceEdit:5263608] May, B, 2014-02-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9965988] Orlic-Milacic, Marija, 2025-09-08
[InstanceEdit:9966308] Orlic-Milacic, Marija, 2025-09-15
namePolycomb Repressive Complex 2 (PRC2) Is recruited to chromatin
output[Complex:3211709] PRC2:Chromatin [nucleoplasm] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[NegativeRegulation:9965983] Negative regulation by 'EPOP:PRC2 [nucleoplasm]'
releaseDate2014-03-12
reviewed[InstanceEdit:5263607] Di Croce, Luciano, 2014-02-11
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:9966046] Orlic-Milacic, Marija, 2025-09-09
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644713] R-HSA-212252.3
structureModified[InstanceEdit:9965988] Orlic-Milacic, Marija, 2025-09-08
summation[Summation:212321] The core of the Polycomb Repressor Complex 2 (PRC2) contains...
(hasEvent)[Pathway:212300] PRC2 methylates histones and DNA [Homo sapiens]
(precedingEvent)[Reaction:212222] PRC2 recruits DNA methyltransferases [Homo sapiens]
[Reaction:212263] PRC2 trimethylates histone H3 at lysine-27 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9971909] Update Tracker - [BlackBoxEvent:212252] Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin - v95:[modifyText, removeRegulator]
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