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Details on Person The human Polycomb Repressive Complex 2 (PRC2) is homologous...

Class:IdSummation:212250
_displayNameThe human Polycomb Repressive Complex 2 (PRC2) is homologous...
_timestamp2010-11-17 09:29:13
created[InstanceEdit:212319] May, B, Gopinathrao, G, 2008-02-08 20:37:25
literatureReference[LiteratureReference:212244] Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
[LiteratureReference:212296] Role of histone H3 lysine 27 methylation in Polycomb-group silencing
[LiteratureReference:212305] Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
[LiteratureReference:212248] Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes
modified[InstanceEdit:1022082] May, B, 2010-11-17
textThe human Polycomb Repressive Complex 2 (PRC2) is homologous to the Drosophila PRC2. The core PRC2 contains EZH2, a histone methyltransferase specific for lysine 27 and lysine 9 of histone H3. The methyltransferase activity of EZH2 is dependent on its association with PRC2. The complex contains other uncharacterized proteins, its composition may vary in different tissues and developmental stages, and the order of assembly of the complex is presently unknown.
(summation)[Complex:212285] PRC2 (EZH2) Core [nucleoplasm] [Homo sapiens]
[Complex:4615881] monoSUMO1-SUZ12:PRC2-EZH2 [nucleoplasm] [Homo sapiens]
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